A series of tests showed progressively diminishing viral presence in the infants blood,until it reached undetectable levels 29 days after birth.
The infant remained on antivirals till 18 months of age.Ten months after the treatment was discontinued,the child underwent repeated blood tests,none of which detected HIV.Test for HIVspecific antibodies the infections standard clinical indicator also remained negative throughout.
Prompt ART in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place, said JHCC virologist Deborah Persaud.
Our next step is to find out if this is a highly unusual response to very early antiretroviral therapy or something we can actually replicate in other high-risk newborns, Persaud added.
The only other HIV-positive person to be cured was Timothy Brown,a middleaged man with leukemia who got cured after receiving a bone-marrow transplant from a donor genetically resistant to HIV infection.
In the current case,the New York Times cited experts saying they needed convincing that the baby had truly been infected in the first place.If not,this would be a case of prevention,something already done for babies born to infected mothers, it reported.Other experts were quoted as saying that the findings in the baby would probably not be relevant to adults.The researchers said they did not have enough data at the moment to recommend changes to the current practice of using preventive rather than therapeutic treatment for high-risk infants.
They said complete viral eradication on a large scale was their long-term goal.But,for now,(it) remains out of reach,and our best chance may come from aggressive,timely and precisely targeted use of antiviral therapies in high-risk newborns as a way to achieve functional cure, the researchers said.
Functional cure allows a patient to be free of the HIV virus without lifelong treatment,besides preventing HIV replication in the blood.In this case,viral presence is so minimal that it remains undetectable by standard clinical tests.It is discernible only through ultrasensitive methods.Prevention is really the best cure,and we already have proven strategies that can prevent 98% of newborn infections by identifying and treating HIV-positive pregnant women, the report said.
The UN estimates that 330,000 babies were infected in 2011.This is apart from more than three million children living with HIV around the world.In India,more than 14,000 children got infected in 2011,which accounted for 13% decline compared to 2009
The infant remained on antivirals till 18 months of age.Ten months after the treatment was discontinued,the child underwent repeated blood tests,none of which detected HIV.Test for HIVspecific antibodies the infections standard clinical indicator also remained negative throughout.
Prompt ART in newborns that begins within days of exposure may help infants clear the virus and achieve long-term remission without lifelong treatment by preventing such viral hideouts from forming in the first place, said JHCC virologist Deborah Persaud.
Our next step is to find out if this is a highly unusual response to very early antiretroviral therapy or something we can actually replicate in other high-risk newborns, Persaud added.
The only other HIV-positive person to be cured was Timothy Brown,a middleaged man with leukemia who got cured after receiving a bone-marrow transplant from a donor genetically resistant to HIV infection.
In the current case,the New York Times cited experts saying they needed convincing that the baby had truly been infected in the first place.If not,this would be a case of prevention,something already done for babies born to infected mothers, it reported.Other experts were quoted as saying that the findings in the baby would probably not be relevant to adults.The researchers said they did not have enough data at the moment to recommend changes to the current practice of using preventive rather than therapeutic treatment for high-risk infants.
They said complete viral eradication on a large scale was their long-term goal.But,for now,(it) remains out of reach,and our best chance may come from aggressive,timely and precisely targeted use of antiviral therapies in high-risk newborns as a way to achieve functional cure, the researchers said.
Functional cure allows a patient to be free of the HIV virus without lifelong treatment,besides preventing HIV replication in the blood.In this case,viral presence is so minimal that it remains undetectable by standard clinical tests.It is discernible only through ultrasensitive methods.Prevention is really the best cure,and we already have proven strategies that can prevent 98% of newborn infections by identifying and treating HIV-positive pregnant women, the report said.
The UN estimates that 330,000 babies were infected in 2011.This is apart from more than three million children living with HIV around the world.In India,more than 14,000 children got infected in 2011,which accounted for 13% decline compared to 2009
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